Barefoot running has a strong neuroscience component because the soles of the feet are fully loaded with key sensory nerves that help regulate landing strategies and withdrawal reflexes at the central nervous system level.

Is Barefoot Running Safe? YES!
Unlike cushioned running shoes which were consistently found to cause more rigid heel strike landings and inappropriate joint loading, especially at the knee, the sensory input when you run barefoot translates into more fast-changing improvements, allowing you to use your leg swing and forefoot strike mechanics as functionally and safely as possible, while helping the feet build more strength and resilience against tough training. This is why barefoot running should be done in the first instance because the ground-feel is the only way to enhance the motor commands for low impact running.